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Published Online: 1 September 2012

Fragmentation and Unpredictability of Early-Life Experience in Mental Disorders

Tallie Z. Baram, M.D., Ph.D., Elysia P. Davis, Ph.D., Andre Obenaus, Ph.D., Curt A. Sandman, Ph.D., Steven L. Small, M.D., Ph.D., Ana Solodkin, Ph.D., and Hal Stern, Ph.D.Authors Info & Affiliations
Publication: American Journal of Psychiatry
Volume 169, Number 9
https://doi.org/10.1176/appi.ajp.2012.11091347
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Abstract

Maternal sensory signals in early life play a crucial role in programming the structure and function of the developing brain, promoting vulnerability or resilience to emotional and cognitive disorders. In rodent models of early-life stress, fragmentation and unpredictability of maternally derived sensory signals provoke persistent cognitive and emotional dysfunction in offspring. Similar variability and inconsistency of maternal signals during both gestation and early postnatal human life may influence development of emotional and cognitive functions, including those that underlie later depression and anxiety.

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Information & Authors

Information

Published In

Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Volume 169 • Number 9 • September 2012
Pages: 907 - 915
PubMed: 22885631

History

Received: 7 September 2011
Revision received: 21 December 2011
Revision received: 8 March 2012
Revision received: 2 April 2012
Accepted: 9 April 2012
Published online: 1 September 2012
Published in print: September 2012

Authors

Affiliations

Tallie Z. Baram, M.D., Ph.D.
From the Departments of Pediatrics, Anatomy/Neurobiology, Neurology, and Psychiatry, School of Medicine, and the Bren School of Information and Computer Sciences, University of California, Irvine; and the Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, Calif.
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Elysia P. Davis, Ph.D.
From the Departments of Pediatrics, Anatomy/Neurobiology, Neurology, and Psychiatry, School of Medicine, and the Bren School of Information and Computer Sciences, University of California, Irvine; and the Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, Calif.
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Andre Obenaus, Ph.D.
From the Departments of Pediatrics, Anatomy/Neurobiology, Neurology, and Psychiatry, School of Medicine, and the Bren School of Information and Computer Sciences, University of California, Irvine; and the Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, Calif.
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Curt A. Sandman, Ph.D.
From the Departments of Pediatrics, Anatomy/Neurobiology, Neurology, and Psychiatry, School of Medicine, and the Bren School of Information and Computer Sciences, University of California, Irvine; and the Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, Calif.
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Steven L. Small, M.D., Ph.D.
From the Departments of Pediatrics, Anatomy/Neurobiology, Neurology, and Psychiatry, School of Medicine, and the Bren School of Information and Computer Sciences, University of California, Irvine; and the Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, Calif.
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Ana Solodkin, Ph.D.
From the Departments of Pediatrics, Anatomy/Neurobiology, Neurology, and Psychiatry, School of Medicine, and the Bren School of Information and Computer Sciences, University of California, Irvine; and the Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, Calif.
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Hal Stern, Ph.D.
From the Departments of Pediatrics, Anatomy/Neurobiology, Neurology, and Psychiatry, School of Medicine, and the Bren School of Information and Computer Sciences, University of California, Irvine; and the Department of Pediatrics, School of Medicine, Loma Linda University, Loma Linda, Calif.
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Notes

Address correspondence to Dr. Baram ([email protected]).

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