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Published Online: 1 October 2012

The Psychiatric Presentation of Mitochondrial Disorders in Adults

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Although comorbid psychiatric illness is increasingly being recognized in patients with mitochondrial disorders, there has been relatively little attention to psychiatric symptomatology as the primary clinical presentation. The authors report detailed clinical, biochemical, neuroradiological, and genetic findings in a series of 12 patients with mitochondrial disorders in whom psychiatric symptoms were a prominent aspect of the clinical presentation. The psychiatric presentations included depression, anorexia nervosa, bipolar disorder, and obsessive-compulsive disorder. A review of the literature, in conjunction with the present series, indicates that psychiatric symptoms can be the presenting feature of mitochondrial disorders and highlights the importance of considering this diagnosis.

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Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 394 - 409
PubMed: 23224446

History

Received: 24 November 2011
Revision received: 1 March 2012
Accepted: 5 March 2012
Published online: 1 October 2012
Published in print: Fall 2012

Authors

Details

Rebecca E. Anglin, M.D., Ph.D., FRCPC
From the Dept. of Psychiatry & Behavioural Neurosciences, Dept. of Pediatrics, Dept. of Medicine (Neurology), McMaster University, Hamilton, Ontario, Canada.
Mark A. Tarnopolsky, M.D., Ph.D., FRCPC
From the Dept. of Psychiatry & Behavioural Neurosciences, Dept. of Pediatrics, Dept. of Medicine (Neurology), McMaster University, Hamilton, Ontario, Canada.
Michael F. Mazurek, M.D., FRCPC
From the Dept. of Psychiatry & Behavioural Neurosciences, Dept. of Pediatrics, Dept. of Medicine (Neurology), McMaster University, Hamilton, Ontario, Canada.
Patricia I. Rosebush, M.D., FRCPC
From the Dept. of Psychiatry & Behavioural Neurosciences, Dept. of Pediatrics, Dept. of Medicine (Neurology), McMaster University, Hamilton, Ontario, Canada.

Notes

Send correspondence to Rebecca Anglin, M.D., St. Joseph’s Healthcare, Hamilton, Ontario; e-mail: [email protected]

Funding Information

Dr. Anglin is supported by an Ontario Mental Health Foundation Research Training Fellowship. Dr. Mark Tarnopolsky has served on the advisory board of Transgenomics. The remainder of the authors do not have any potential conflicts of interest pertaining to this manuscript.
Funding for this project was provided by Physicians Services Incorporated (Grant R06-24).
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