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Research Article
Published Online: November 1986

Variability of response to lithium augmentation in refractory depression

Publication: American Journal of Psychiatry

Abstract

Eighty-four patients with major depression refractory to a controlled antidepressant trial had lithium added to their ongoing treatment. Objective symptom ratings showed highly significant improvement in the sample as a whole. At discharge or after 24 days, 31% of the patients showed a marked response, 25% a partial response. Thus, 56% of patients had a significant positive response, while 44% were nonresponders. This study indicates that response to lithium augmentation may be quite variable and a 3-week trial is necessary to assess full benefit.

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Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 1387 - 1392
PubMed: 3096155

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Published in print: November 1986
Published online: 1 April 2006

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