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Published Online: 1 September 2000

Cerebrovascular Risk Factors and 1-Year Depression Outcome in Older Primary Care Patients

Publication: American Journal of Psychiatry

Abstract

OBJECTIVE: A model in which cerebrovascular disease contributes to the pathogenesis of depression in later life was the basis of the authors’ hypothesis that cerebrovascular risk factors at intake are independently associated with depression at 1-year follow-up. METHOD: The subjects were 247 patients aged 60 years or older in primary care practices. The study measures were completed at intake and 1-year follow-up. Multiple regression techniques were used to determine the independent association of initial cerebrovascular risk factors with depressive symptoms and diagnoses at 1 year. RESULTS: The authors found that the severity of initial cumulative cerebrovascular risk factors was significantly independently associated with 1-year depressive symptoms and diagnoses, but not after also controlling for overall medical burden. CONCLUSIONS: The results lend some support to the cerebrovascular model of depression.

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Go to American Journal of Psychiatry
Go to American Journal of Psychiatry
American Journal of Psychiatry
Pages: 1499 - 1501
PubMed: 10964868

History

Published online: 1 September 2000
Published in print: September 2000

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Jeffrey M. Lyness, M.D.
Deborah A. King, Ph.D.
Christopher Cox, Ph.D.

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