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Abstract

HIV-negative individuals with a family history of dementia (FHD) are more likely to develop dementia than those without FHD. Whether FHD increases risk for neuropsychological (NP) impairment in HIV+ persons is unknown. As part of a multisite study into HIV-associated neurocognitive disorders (HAND), the authors captured FHD with a free-response, self-report question, and assessed NP performance with a comprehensive battery of tests. The authors examined HIV+ persons with (N=190) and without (N=916) self-reported FHD. Despite the fact that the FHD group had factors typically associated with better NP performance (e.g., higher CD4 counts and estimated verbal IQ), persons with FHD had significantly worse NP ability than those without FHD as measured by a Global Deficit Score. Thus, FHD appears to be a risk factor for HAND; the mechanism(s) underlying how FHD contributes to NP impairment among HIV+ persons warrants study.

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Information & Authors

Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 316 - 323
PubMed: 21948893

History

Received: 20 October 2010
Revision requested: 4 February 2011
Accepted: 31 March 2011
Published online: 1 July 2011
Published in print: Summer 2011

Keywords

  1. Dementia
  2. Family History
  3. HIV
  4. Neuropsychological Functioning
  5. Cognition

Authors

Details

David J. Moore, Ph.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Miguel Arce, B.A.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Suzanne Moseley, B.S.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
J. Allen McCutchan, M.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Jennifer Marquie-Beck, M.P.H.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Donald R. Franklin, B.S.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Florin Vaida, Ph.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Cristian L. Achim, M.D., Ph.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Justin McArthur, M.B.B.S., M.P.H.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Susan Morgello, M.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
David M. Simpson, M.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Benjamin B. Gelman, M.D., Ph.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Ann C. Collier, M.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Christina M. Marra, M.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
David B. Clifford, M.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Robert K. Heaton, Ph.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
Igor Grant, M.D.
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.
The Charter Group and The HNRC Group
From the Dept. of Psychiatry, University of California, San Diego (UCSD) and the HIV Neurobehavioral Research Center (HNRC), UCSD; the Dept. of Medicine, UCSD Division of Biostatistics and Bioinformatics; Johns Hopkins University; Baltimore, MD; Mount Sinai School of Medicine, New York, NY; University of Texas Medical Branch, Galveston, TX; University of Washington, Seattle; and Washington University, St. Louis, MO.

Notes

Correspondence: David J. Moore, Ph.D.; [email protected] (e-mail).

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