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Clinical Research Reports
Published Online: 1 July 2011

Determining the Impact of Dementia on Antidepressant Treatment Response in Older Adults

Publication: The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Major depression is a common diagnosis in older individuals. The authors present preliminary findings on the response to sertraline in depressed elderly patients with and without dementia. Previous research on antidepressant treatment in elderly patients suggests that it is effective in treating depression. The authors followed depressed patients with and without dementia. Treatment response was more marked in the subgroup without dementia, but there was no statistically significant difference in response between the two subgroups. Depressed elderly patients with dementia may improve on antidepressant treatment, although treatment response may be less robust than in depressed patients without dementia.

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Information

Published In

Go to The Journal of Neuropsychiatry and Clinical Neurosciences
Go to The Journal of Neuropsychiatry and Clinical Neurosciences
The Journal of Neuropsychiatry and Clinical Neurosciences
Pages: 358 - 361
PubMed: 21948898

History

Received: 23 December 2009
Revision requested: 3 March 2010
Accepted: 5 November 2010
Published online: 1 July 2011
Published in print: Summer 2011

Keywords

  1. Dementia
  2. Antidepressants
  3. Geriatrics

Authors

Details

Corinne E. Fischer, M.D., FRCPC
From the Department of Psychiatry affiliated with the Keenan Research Centre of the Li Ka Shing Knowledge Research Institute, St. Michael's Hospital, #30 Bond St., Toronto, Ontario, M5B 1W8; and FRCPC, Rm. 17044, 30 Bond St. Toronto, Ontario, M57B 1W8, Canada.
Tom A. Schweizer, Ph.D.
From the Department of Psychiatry affiliated with the Keenan Research Centre of the Li Ka Shing Knowledge Research Institute, St. Michael's Hospital, #30 Bond St., Toronto, Ontario, M5B 1W8; and FRCPC, Rm. 17044, 30 Bond St. Toronto, Ontario, M57B 1W8, Canada.
Jemcy Joy, B.Sc.
From the Department of Psychiatry affiliated with the Keenan Research Centre of the Li Ka Shing Knowledge Research Institute, St. Michael's Hospital, #30 Bond St., Toronto, Ontario, M5B 1W8; and FRCPC, Rm. 17044, 30 Bond St. Toronto, Ontario, M57B 1W8, Canada.
Depeng Jiang, Ph.D.
From the Department of Psychiatry affiliated with the Keenan Research Centre of the Li Ka Shing Knowledge Research Institute, St. Michael's Hospital, #30 Bond St., Toronto, Ontario, M5B 1W8; and FRCPC, Rm. 17044, 30 Bond St. Toronto, Ontario, M57B 1W8, Canada.
Lee Ringer, B.Sc., M.Sc.N.
From the Department of Psychiatry affiliated with the Keenan Research Centre of the Li Ka Shing Knowledge Research Institute, St. Michael's Hospital, #30 Bond St., Toronto, Ontario, M5B 1W8; and FRCPC, Rm. 17044, 30 Bond St. Toronto, Ontario, M57B 1W8, Canada.
Nathan Herrmann, M.D., FRCPC
From the Department of Psychiatry affiliated with the Keenan Research Centre of the Li Ka Shing Knowledge Research Institute, St. Michael's Hospital, #30 Bond St., Toronto, Ontario, M5B 1W8; and FRCPC, Rm. 17044, 30 Bond St. Toronto, Ontario, M57B 1W8, Canada.

Notes

Correspondence: Corinne Fischer, M.D; [email protected] (e-mail).

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