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Published Online: 1 January 2012

Predictors of Relapse in the Year After Hospital Discharge Among Patients With Schizophrenia

Publication: Psychiatric Services

Volume 63, Number 1

https://doi.org/10.1176/appi.ps.201100084

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Abstract

Objective:

Relapse and its predictors were examined among patients with schizophrenia in the year after hospital discharge.

Methods:

The sample included 200 patients with schizophrenia participating in a German multicenter study. Relapse was defined as a worsening of psychopathological symptoms or rehospitalization in the year after hospital discharge. Predictors examined were variables related to course of illness and to response and remission at discharge.

Results:

Fifty-two percent of participants had a relapse. Patients whose symptoms were not in remission at discharge were more likely to have a relapse, as were those who had more severe symptoms and more side effects at discharge. Those who experienced a relapse were less likely to be taking a second-generation antipsychotic at discharge, less likely to have a positive attitude toward treatment adherence, and less likely to be employed.

Conclusions:

The high rate of relapse among patients with schizophrenia highlights the need to improve current treatment strategies. (Psychiatric Services 63:87–90, 2012)

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Figure 1 Relapse during the year after hospital discharge among 200 patients, by whether their symptoms had responded to treatment or were in remission at discharge

Information & Authors

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Cover: Mount Vesuvius, by Andy Warhol, 1985. Museo Nazionale di Capodimonte, Naples, Italy. © The Andy Warhol Foundation for the Visual Arts, Inc/Artists Rights Society, New York.

Psychiatric Services

Volume 63 • Number 1 • January 2012

Pages: 87 - 90

PubMed: 22227766

History

Published online: 1 January 2012

Published in print: January 2012

Authors

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Rebecca Schennach, M.D. [email protected]

Dr. Schennach, Mr. Obermeier, Mr. Meyer, Prof. Jäger, Dr. Seemüller, Prof. Möller, and Prof. Riedel are affiliated with the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nussbaumstreet 7, 80336 Munich, Germany (e-mail: [email protected]).

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Michael Obermeier [email protected]

Dr. Schennach, Mr. Obermeier, Mr. Meyer, Prof. Jäger, Dr. Seemüller, Prof. Möller, and Prof. Riedel are affiliated with the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nussbaumstreet 7, 80336 Munich, Germany (e-mail: [email protected]).

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Sebastian Meyer [email protected]

Dr. Schennach, Mr. Obermeier, Mr. Meyer, Prof. Jäger, Dr. Seemüller, Prof. Möller, and Prof. Riedel are affiliated with the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nussbaumstreet 7, 80336 Munich, Germany (e-mail: [email protected]).

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Markus Jäger, M.D. [email protected]

Dr. Schennach, Mr. Obermeier, Mr. Meyer, Prof. Jäger, Dr. Seemüller, Prof. Möller, and Prof. Riedel are affiliated with the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nussbaumstreet 7, 80336 Munich, Germany (e-mail: [email protected]).

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Max Schmauss, M.D.

Prof. Schmauss is with the Psychiatric Clinic, District Hospital Augsburg, Augsburg, Germany.

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Gerd Laux, M.D.

Prof. Laux is with the Psychiatric Clinic, Inn-Salzach Hospital, Wasserburg-Inn, Germany.

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Herbert Pfeiffer, M.D.

Dr. Pfeiffer is with the Psychiatric Clinic, Isar-Amper Hospital, Munich-Haar, Germany.

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Dieter Naber, M.D.

Prof. Naber is with the Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Germany.

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Lutz G. Schmidt, M.D.

Prof. Schmidt is with the Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany.

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Wolfgang Gaebel, M.D.

Prof. Gaebel is with the Department of Psychiatry and Psychotherapy, Heinrich-Heine-University, Duesseldorf, Germany.

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Joachim Klosterkötter, M.D.

Prof. Klosterkötter is with the Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.

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Isabella Heuser, M.D.

Prof. Heuser is with the Department of Psychiatry and Psychotherapy, Charite Berlin, Campus Benjamin Franklin, Berlin, Germany.

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Wolfgang Maier, M.D.

Prof. Maier is with the Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.

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Matthias R. Lemke, M.D.

Prof. Lemke is with the Department of Psychiatry, Alsterdorf Hospital, Hamburg, Germany.

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Eckart Rüther, M.D.

Prof. Rüther is with the Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany.

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Stefan Klingberg, M.D.

Prof. Klingberg is with the Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

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Markus Gastpar, M.D.

Prof. Gastpar is with the Fliedner Clinic, Berlin, Germany.

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Florian Seemüller, M.D. [email protected]

Dr. Schennach, Mr. Obermeier, Mr. Meyer, Prof. Jäger, Dr. Seemüller, Prof. Möller, and Prof. Riedel are affiliated with the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nussbaumstreet 7, 80336 Munich, Germany (e-mail: [email protected]).

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Hans-Jürgen Möller, M.D. [email protected]

Dr. Schennach, Mr. Obermeier, Mr. Meyer, Prof. Jäger, Dr. Seemüller, Prof. Möller, and Prof. Riedel are affiliated with the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nussbaumstreet 7, 80336 Munich, Germany (e-mail: [email protected]).

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Michael Riedel, M.D. [email protected]

Prof. Riedel is also with the Psychiatric Clinic, Vinzenz-von-Paul-Hospital, Rottweil, Germany.

Dr. Schennach, Mr. Obermeier, Mr. Meyer, Prof. Jäger, Dr. Seemüller, Prof. Möller, and Prof. Riedel are affiliated with the Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Nussbaumstreet 7, 80336 Munich, Germany (e-mail: [email protected]).

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