Sections
History and Discovery | Structure–Activity Relations | Pharmacological Profile | Pharmacokinetics and Disposition | Indications and Efficacy | Side Effects and Toxicology | Drug–Drug Interactions | Conclusion | References
Excerpt
Mirtazapine, originally known as ORG 3770, was first synthesized
by the Department of Medicinal Chemistry of NV Organon in the Netherlands
(Kaspersen et al. 1989). First approved for use in
major depression in the Netherlands in 1994, mirtazapine was introduced
in the United States in 1996. The new drug application consisted
of 47 Phase II/III clinical trials involving 2,796 mirtazapine-treated
patients, 605 placebo-treated patients, and 1,161 active-control
patients (Fawcett and Barkin 1998b).