Buspirone and Gepirone

Donald Robinson; Karl Rickels; Frank Yocca

The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition >

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Chapter 25. Buspirone and Gepirone

Donald S. Robinson, M.D.; Karl Rickels, M.D.; Frank D. Yocca, Ph.D.

DOI: 10.1176/appi.books.9781585623860.428442

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Evidence of altered central serotonergic function exists for several of the psychiatric disorders, especially the mood and anxiety disorders. Discovery of the serotonin_1A (5-HT_1A) receptor was instrumental in linking modulation of serotonin neurotransmission to anxiety symptoms. Similarly, the tricyclic antidepressants (TCAs) and the selective serotonin reuptake inhibitors (SSRIs) implicated serotonin in the pathophysiology and treatment of depression.

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CME Activity

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Sample questions:

Which of the following is descriptive of buspirone’s pharmacological profile?

Which of the following statements concerning buspirone’s pharmacokinetic profile is true?

You are considering switching your patient, who has been taking a benzodiazepine for 2 years for generalized anxiety disorder (GAD), to buspirone. Which of the following describes an important study finding directly relevant to this decision?

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).

Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.

All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.

Chapter 25. Buspirone and Gepirone

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