Buspirone and Gepirone: Introduction | The 5-HT1A Receptor | Buspirone | Gepirone | Conclusion | References
Evidence of altered central serotonergic function
exists for several of the psychiatric disorders, especially the mood
and anxiety disorders. Discovery of the serotonin1A (5-HT1A)
receptor was instrumental in linking modulation of serotonin neurotransmission
to anxiety symptoms. Similarly, the tricyclic antidepressants (TCAs)
and the selective serotonin reuptake inhibitors (SSRIs) implicated serotonin
in the pathophysiology and treatment of depression.