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Chapter 20. Sleep Disturbance and Fatigue

Sandeep Vaishnavi, M.D., Ph.D.; Michael Makley, M.D.; Vani Rao, M.D.
DOI: 10.1176/appi.books.9781585624201.680108

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Sleep disturbance and fatigue are two common disabling symptoms that affect the recovery course and disrupt rehabilitation in patients who survive traumatic brain injury (TBI). Despite the ubiquity of these problems, objective data are scarce on the prevalence, pathophysiology, and treatment of these conditions in the TBI literature. The exact etiology of these disturbances is also unclear. Sleep disturbance and fatigue after TBI can be best conceptualized as primary effects of the trauma itself, which can cause neurohormonal and neurotransmitter dysfunction in the central nervous system or as secondary effects of neuropsychiatric disturbances associated with the TBI. Side effects of medications used to treat TBI and psychological distress associated with trauma may also influence sleep cycle integrity. Sleep disturbance and fatigue, although not well studied after TBI, are common and have important rehabilitation implications for patients (see Figure 20–1).

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