0
0

Sections

Excerpt

The one gene with a clearly established relationship to late-onset AD is APOE, with increased risk of AD found in individuals carrying the 4 allele (APOE*E4) in both familial and sporadic cases (Brousseau et al. 1994; Mayeux et al. 1993; Rebeck et al. 1993; Saunders et al. 1993; Schmechel et al. 1993). The risk for AD increases, and the mean age of onset of AD is earlier, as the number of 4 alleles an individual carries increases from 0 to 2 (Corder et al. 1993). These findings were confirmed in a meta-analysis of more than 14,000 subjects who were recruited from clinical, community, and brain bank sources, representing multiple ethnic groups (Farrer et al. 1997). Importantly, although the effect of APOE*E4 on increased risk of AD was evident in both sexes and in all age and ethnic groups, the magnitude of the risk associated with APOE*E4 varied by age and ethnicity. Specifically, the risk appeared to be attenuated in older individuals and in African American and Hispanic individuals (relative to whites). In contrast, the risk conferred by APOE*E4 was increased in individuals of Japanese ethnicity.

Your session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Related Content
Articles
Books
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 8.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 11.  >
The American Psychiatric Publishing Textbook of Geriatric Psychiatry, 4th Edition > Chapter 11.  >
The American Psychiatric Publishing Textbook of Geriatric Psychiatry, 4th Edition > Chapter 13.  >
Psychiatric News
Read more at Psychiatric News >>
PubMed Articles
 
  • Print
  • PDF
  • E-mail
  • Chapter Alerts
  • Get Citation