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Compared with unipolar depression, mania following a stroke is relatively uncommon. However, a controlled study of patients with secondary mania showed that when manic symptoms are present, the right hemisphere of the brain (both cortical and subcortical areas) is more frequently the site of the lesion (Starkstein et al. 1987, 1991). Further research suggests that development of mania after right-sided lesions occurs more often when the basal region of the right temporal lobe is involved (Starkstein et al. 1990).

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