Structures | Pharmacological Effects | Indications | Blood Levels | Side Effects | Overdose | Dosage and Administration | Discontinuation
The chemical structures of TCAs and related compounds are
remarkably similar (Figure 3–6). Desipramine and nortriptyline
are demethylated metabolites of imipramine and amitriptyline, respectively.
Amoxapine is a derivative of the antipsychotic loxapine and has
an additional fourth ring off a side chain. Maprotiline is a four-ring
compound, with the fourth ring arising perpendicular to the traditional
three rings. Its side chain is identical to that of desipramine.