0
0

Sections

Excerpt

There are, at the time of this writing, 21 antipsychotic drugs available for prescription use in the United States: 12 first-generation antipsychotic agents and 9 second-generation antipsychotic agents (Table 4–1; Figure 4–1). One of the first-generation agents, pimozide, is FDA approved for use only in Tourette's disorder and is now rarely used because of the known risk of QTc prolongation. Likewise, droperidol, another agent with a black box warning of QTc prolongation, is approved only for parenteral use in anesthesia. Studies done on the rate of arrhythmias in droperidol-treated patients since the black box warning in 2001 have not necessarily supported an enhanced risk (Nuttall et al. 2007). All the antipsychotic agents, except clozapine, are reasonably potent postsynaptic dopamine receptor blockers (dopamine antagonists). Although it is conceivable that the antipsychotic effects of these drugs might be attributable to some other mechanism, it seems unlikely. While some of the efficacy of the SGAs may be due to 5-HT2 antagonism or the blockade of other dopamine receptors, agents that purely block 5-HT2 or dopamine receptors other than D2 have often failed as effective antipsychotics.

Your session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

Table Reference Number
Table 4–1. Antipsychotic drugs: names, formulations, and strengths
Table Reference Number
Table 4–2. Antipsychotic drug potency

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Related Content
Articles
Books
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 1.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 3.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 4.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 8.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 10.  >
Psychiatric News
Read more at Psychiatric News >>
PubMed Articles
 
  • Print
  • PDF
  • E-mail
  • Chapter Alerts
  • Get Citation