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In some respects, the treatment of acute mania is among the least problematic components of treating bipolar disorder. Patients with bipolar disorder spend much less time in mania, hypomania, or mixed states than they do in depression. In addition, there are many effective treatments for mania but few for maintenance treatment or treatment of bipolar depression. There are four classes of medications effective in the treatment of acute mania; first-generation antipsychotics, SGAs, anticonvulsants, and lithium. The pharmacotherapy of mania often requires combinations of these agents.

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