ADHD is the only condition other than narcolepsy and weight reduction for which stimulants are currently approved by the FDA. In children, the syndrome is manifested by very short attention span, overactivity, irritability, poor social relations, impulsivity, occasional angry or assaultive behavior, poor school performance, and apparent inability to benefit from instruction or limit setting. Some children with the syndrome have a parent with a history or current symptoms of a similar condition. Occasional children with the syndrome have clear evidence of central nervous system (CNS) damage at birth or subsequently; the majority of such patients, however, do not have "hard" neurological signs of clearly diagnosable brain injury or abnormality.