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Lithium is perhaps the best-studied augmenter to antidepressants in patients with treatment-resistant depression (TRD). There are more lithium augmentation trials than there are augmentation studies using any other agent in TRD. However, the total number of subjects in all of these trials probably does not equal the number of subjects in the registration trials of one SGA in the treatment of TRD. In addition, saying lithium is the best studied augmenter is different from saying lithium is the best augmenter or the strategy that should be used before others are attempted. Lithium can be cumbersome to use, requiring careful titration and serum level monitoring, and can be lethal in overdose. An ever-growing number of augmentation strategies have been proposed, but lithium remains an important option for TRD.

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Table Reference Number
Table 9–2. Prepackaged combination antidepressants: names, formulations and strengths, and dosages

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