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Adult twin studies suggest that genetic influences explain approximately 60%–93% of the variance in BP, while shared and unique environmental factors account for 30%–40% and 10%–21%, respectively (reviewed in Althoff et al. 2005). There are no "narrow phenotype" twin studies of early-onset BP. BP-I rates are elevated in relatives of children with narrow-phenotype BP but not in broad phenotype/severe mood dysregulation (Brotman et al. 2007) though they may cosegregate in certain families.

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Table Reference Number
TABLE 19–4. Reports of offspring studies in parents with bipolar disorder (BP)

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