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Medical conditions or syndromes are thought to be responsible for less than 10% of all cases of childhood obesity. However, when present, these disorders can have substantial effects. Endogenous causes for obesity may include hormonal causes such as hypothyroidism, hypercortisolism, primary hyperinsulinism, pseudohypoparathyroidism, and acquired hypothalamic dysfunction. Familial lipodystrophy conditions including Beckwith-Wiedermann, Sotos, Weaver, and Ruvalcaba disorders may also be associated with pediatric obesity (Zametkin et al. 2004). Certain genetic syndromes have been linked with obesity, including Prader-Willi, Laurence-Moon/Bardet-Biedl, Alstrom, Borjeson-Forssman-Lehmann, Cohen, and Turner syndromes.

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