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Brent et al.'s (1997) study of depressed adolescents included suicidal teens; findings indicate that cognitive-behavioral therapy (CBT) was superior to both family and supportive therapies in the treatment of depressive symptoms, but all three treatments were associated with similar reductions in suicidality. In the multisite Treatment of Adolescent Depression Study (TADS) in which fluoxetine, CBT, and the combination were compared with each other and with placebo, both fluoxetine and the combination produced substantial improvements in depression relative to placebo and CBT alone, but only the combination was associated with decreased suicidal ideation as compared to placebo (March et al. 2004).

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