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No studies have expressly examined the effect of fluoxetine or any other selective serotonin reuptake inhibitors (SSRIs) on impulsive aggression in youth. Findings from the TADS indicate that fluoxetine is superior to placebo for the treatment of depression in youth but is not associated with greater decreases in suicidal ideation. It is important to note, however, that all groups exhibited a significant decrease in suicidal ideation (March et al. 2004). Recent findings from the Treatment of Resistant Depression in Adolescents (TORDIA) study of teens who did not respond to an adequate initial SSRI trial indicate that switch to a different SSRI was just as efficacious as switch to venlafaxine; there were no differences in rates of suicidality between groups (Brent et al. 2008).

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