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Chapter 45. Principles of Psychopharmacology

Noah L. Miller, M.D.; Robert L. Findling, M.D.
DOI: 10.1176/appi.books.9781585623921.467748

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Excerpt

When clinicians contemplate the therapeutic options for psychiatric disorders, psychopharmacotherapy is often one of those options. However, there are many considerations in thinking about treatment for a youngster with a psychiatric disorder. These considerations differ from those for adults with a psychiatric disorder or for children with pediatric disorders. Factors that make psychopharmacotherapy in children and adolescents distinct from both psychopharmacotherapy in adults and pharmacotherapy for general medical conditions in children include the following:

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Table Reference Number
TABLE 45–1. Selected areas of the psychiatric assessment that are important to pediatric psychopharmacology
Table Reference Number
TABLE 45–2. Laboratory tests to check during the psychopharmacological assessment of a pediatric patient

References

Achenbach TM, Rescorla LA: Manual for the ASEBA School-Age Forms and Profiles. Burlington, University of Vermont, Research Center for Children, Youth, and Families, 2001
 
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision. Washington, DC, American Psychiatric Association, 2000
 
Bradley C: The behavior of children receiving Benzedrine. Am J Orthopsychiatry 94:577–585, 1937
 
Chen N, Aleksa K, Woodland C, et al: Ontogeny of drug elimination by the human kidney. Pediatr Nephrol 21:160–168, 2006
[PubMed]
 
Conners CK: Conners 3rd Edition. North Tonawanda, NY, Multi-Health Systems, 2008
 
Connor D, Meltzer B: A brief history of the field, in Pediatric Psychopharmacology Fast Facts. New York, WW Norton, 2006, pp 4–6
 
Hazell P, O'Connell D, Heathcote D, et al: Tricyclic drugs for depression in children and adolescents. Cochrane Database of Systematic Reviews 2002, Issue 2. Art. No.: CD002317. DOI: 10.1002/14651858.CD002317
 
Ivanova MY, Dobrean A, Dopfner M, et al: Testing the 8-syndrome structure of the Child Behavior Checklist in 30 societies. J Clin Child Adolesc Psychol 36:405–417, 2007
[PubMed]
 
Jatlow PI: Psychotropic drug disposition during development, in Psychiatric Pharmacosciences of Children and Adolescents. Edited by Popper C. Washington, DC, American Psychiatric Press, 1987, pp 27–44
 
Kearns GL, Abdel-Rahman SM, Alander SW, et al: Developmental pharmacology: drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157–1167, 2003
[PubMed]
 
McNally P, McNichols F, Oslizlok P: The QT interval and psychotropic medications in children: recommendations for clinicians. Eur Child Adolesc Psychiatry 16:33–47, 2007
[PubMed]
 
Murrin LC, Sanders JD, Bylund DB: Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: implications for differential drug effects on juveniles and adults. Biochem Pharmacol 73:1225–1236, 2007
[PubMed]
 
U.S. Food and Drug Administration: Public Health Advisory: Suicidality in Children and Adolescents Being Treated with Anti-depressant Medications. October 15, 2004. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm155488.htm. Accessed June 23, 2009.
 
U.S. Food and Drug Administration: Safety Alerts for Human Medical Products: Antiepileptic Drugs. January 31, 2008. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm074939.htm. Accessed June 23, 2009.
 
Vitiello B: Developmental aspects of pediatric psychopharmacology, in Clinical Manual of Child and Adolescent Psychopharmacology. Edited by Findling RL. Washington, DC, American Psychiatric Publishing, 2008, pp 1–31
 
Zametkin AJ, Ernst M, Silver R: Laboratory and diagnostic testing in child and adolescent psychiatry: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry 37:464–472, 1998
[PubMed]
 
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CME Activity

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Sample questions:
1.
Which of the following goals needs to be reached during a psychiatric assessment of youth before considering psychopharmacological treatment?
2.
Which of the following medications is least likely to affect electrocardiogram (ECG) at therapeutic doses?
3.
All of the following statements regarding the principles of diagnosing and treating youth with psychiatric disorders are correct except
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