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Once or twice
Mechanism of action: noradrenergic-specific reuptake inhibitor
Mild/moderate appetite decrease
Mild initial weight loss
Cardiovascular effects (mild increase in blood pressure, pulse)
No ECG conduction or repolarization delays
Rare serious hepatotoxicity
Uncommon increase in suicidal thoughts
are general guidelines. All doses must be individualized with appropriate
monitoring. Weight-corrected doses are less appropriate for obese
children. When high doses are used, serum levels may be obtained
in order to avoid toxicity. FDA-approved total daily dose: 1.4 mg/kg
ADHD = attention-deficit/hyperactivity disorder;
ANX = anxiety disorders; ECG = electrocardiogram;
TIC = tic disorder.