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Bupropion hydrochloride is a novel-structured antidepressant of the aminoketone class related to the phenylisopropylamines but pharmacologically distinct from known antidepressants. Although its specific site or mechanism of action remains unknown, bupropion seems to have an indirect mixed agonist effect on dopamine and norepinephrine neurotransmission. Bupropion has been shown to be effective for ADHD in children in a controlled multisite study (N = 72) (Casat et al. 1987, 1989; Conners et al. 1996) and in a comparison with methylphenidate (N = 15) (Barrickman et al. 1995). A double-blind, controlled clinical trial of bupropion in adults with ADHD documented superiority over placebo (Wilens et al. 1999c, 2005), with an effect size highly consistent with the pediatric trials.

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