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Trazodone is a triazolopyridine derivative with a structure unique to other antidepressants. However, it does resemble side-chain groups of phenothiazines and TCAs. Its triazole moiety is thought to confer antidepressant properties. Trazodone blocks presynaptic reuptake of serotonin with lower potency than SSRIs. It is relatively specific and has negligible effects on dopamine or norepinephrine reuptake. Other serotonergic effects of this drug are complex and include serotonin receptor antagonism, particularly 5-HT2. Its major active metabolite, m-chlorophenylpiperazine (m-CPP), is a potent serotonin agonist. Thus, trazodone is a serotonin reuptake inhibitor and a mixed serotonergic agonist and antagonist.

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