Chemical Structure and Pharmacology | Pharmacokinetics | Adverse Effects Profile | Efficacy
Trazodone is a triazolopyridine derivative with a structure
unique to other antidepressants. However, it does resemble side-chain
groups of phenothiazines and TCAs. Its triazole moiety is thought
to confer antidepressant properties. Trazodone blocks presynaptic reuptake
of serotonin with lower potency than SSRIs. It is relatively specific
and has negligible effects on dopamine or norepinephrine reuptake.
Other serotonergic effects of this drug are complex and include
serotonin receptor antagonism, particularly 5-HT2.
Its major active metabolite, m-chlorophenylpiperazine (m-CPP),
is a potent serotonin agonist. Thus, trazodone is a serotonin reuptake
inhibitor and a mixed serotonergic agonist and antagonist.