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Central nervous system
Tremor, sedation, headache
Use a slow-release formulation; dose twice daily.
Collaborate with primary care physician for management
Consult with endocrinologist; augment with triiodothyronine.
Split into 2–3 daily doses. Use a slow-release formulation.
Encourage diet and exercise. Consider a trial of metformin
(Klein et al. 2006).
Polyuria, decreases in renal function
Write note to school that allows the patient to go to
the bathroom as needed during school; monitor serum creatinine or
creatinine clearance, serum urea nitrogen, and urine osmolality
every 6 months.