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Other Medications With Sedating Properties

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There is no significant research evidence supporting the use of sedating antidepressants in the treatment of pediatric insomnia. Although a clinician could argue that using a sedating antidepressant (for example, mirtazapine) is appropriate when treating insomnia associated with clinical depression, it may not be the best choice. In our estimate, it may be more efficacious to treat the depression with a serotonin reuptake inhibitor such as fluoxetine while adding a sedating medication such as melatonin, a benzodiazepine, or a nonbenzodiazepine benzodiazepine receptor agonist in the short-term as the depression resolves.

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