Dopaminergic neurons in the mesolimbic region project from the ventral tegmental area (VTA) to the NAcc. The NAcc may be crucially important in producing the rewarding actions of ethanol (Weiss and Porrino 2002). Ethanol administration enhances dopamine release in the NAcc (Di Chiara and Imperato 1988; Yim and Gonzales 2000), which may result from ethanol-induced increases in the firing rate of dopamine cells located in the VTA (Brodie et al. 1999; Gessa et al. 1985). The repeated administration of ethanol may result in sensitization of dopamine VTA neurons to the effects of ethanol on dopamine cell firing (Brodie 2002). However, during acute withdrawal from ethanol, spontaneous activity of dopamine cells in the VTA is decreased (Shen and Chiodo 1993), as is dopamine release in the NAcc (Weiss et al. 1996).

Your session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).


Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Related Content
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 6.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 7.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 8.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 4.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 4.  >
Psychiatric News
PubMed Articles
Nicotine: alcohol reward interactions. Neurochem Res 2010;35(8):1248-58.doi:10.1007/s11064-010-0181-8.
Interaction of the nicotinic cholinergic system with ethanol withdrawal. J Pharmacol Exp Ther 2004;308(2):591-9.doi:10.1124/jpet.103.059758.
  • Print
  • PDF
  • E-mail
  • Chapter Alerts
  • Get Citation