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FIGURE 4–6. Darkfield photomicrographs of (A) dopamine transporter (DAT)–, (B) tyrosine hydroxylase (TH)–, and (C) dopamine <img src='images/special/betalower.gif' border='0'/>-hydroxylase

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FIGURE 4–6. Darkfield photomicrographs of (A) dopamine transporter (DAT)–, (B) tyrosine hydroxylase (TH)–, and (C) dopamine -hydroxylase (DBH)–immunoreactive axons in adjacent sections through vermal lobule VIIIB of macaque monkey cerebellum.Note that both the TH- and DAT-immunoreactive axons are primarily restricted to the granule cell layer (GC), with some clusters of axons extending into the Purkinje cell layer. TH-immunoreactive axons are also present in the molecular layer (ML), but no DAT-immunoreactive axons are detectable in this layer. In contrast, DBH-immunoreactive axons are distributed across all layers. In addition, the restricted lobular distribution of DAT-immunoreactive axons is illustrated by the marked paucity of these axons in the GC (asterisks in B) of the folium across the white matter, whereas the density of DBH-immunoreactive axons does not seem to differ across lobules. Scale bar = 150 m.Source. Reprinted from Melchitzky DS, Lewis DA: "Tyrosine Hydroxylase- and Dopamine Transporter–Immunoreactive Axons in the Primate Cerebellum: Evidence for a Lobular- and Laminar-Specific Dopamine Innervation." Neuropsychopharmacology 22:466–472, 2000. Copyright 2000, Elsevier. Used with permission.

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