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P-glycoprotein (T1236C, G2677T, C3435T)
Increased drug bioavailability
Digoxin, fexofenadine, methadone, olanzapine, aripiprazole,
risperidone, paliperidone, citalopram, sertraline, amitriptyline,
buspirone, clozapine, fluvoxamine, haloperidol, nortriptyline, venlafaxine
High drug concentrations; possible toxicity
Desipramine, nortriptyline, codeine, dextromethorphan
Reduced substrate clearance
Tolbutamide, S-warfarin, phenytoin
High drug concentrations; increased sedation and possible
Greater toxicity; peripheral neuritis; skin eruptions
atypical cholinesterase forms
Note. CYP = cytochrome
P450; NAT-2 = N-acetyltransferase
Source. Kalow and Genest 1957; Lockridge 1990; Meyer et al. 1990; Price Evans 1993; Relling et al. 1991.
aShimada et al. 1994.
bBenet et al. 1996; Wrighton and Stevens 1992.