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Chapter 9. Brain–Immune System InteractionsRelevance to the Pathophysiology and Treatment of Neuropsychiatric Disorders

Charles L. Raison, M.D.; Monica Kelly Cowles, M.D., M.S.; Andrew H. Miller, M.D.
DOI: 10.1176/appi.books.9781585623860.417357

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Excerpt

Although once considered heresy, the notion that meaningful interactions occur between the brain and the immune system has become scientific dogma. This change in scientific orthodoxy results from more than 30 years of research demonstrating that brain-mediated events, such as psychological stress and depression, can alter peripheral immune system functioning and, conversely, that changes in peripheral immune functioning, such as those that occur during illness, can profoundly affect the brain, leading to clinically meaningful changes in mood, anxiety, and cognition. In this chapter, we provide an overview of brain–immune system interactions that are of potential relevance to the field of psychiatry.

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Table Reference Number
TABLE 9–1. Major divisions of the immune response
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TABLE 9–2. Immune alterations in major depression
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TABLE 9–3. Evidence that cytokines can alter central nervous system function
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TABLE 9–4. Potential mechanisms by which cytokines may influence behavior

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Which of the following cells are parts of the body’s immune response?
2.
An acquired immune system response consists of various phases. In which phase does the presence of an antigen trigger the expansion of antigen-specific T and B cells?
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Major depression has been found to be associated with profound alterations in immunological responses. Which of the following have been reported?
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