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For a variety of reasons, from the perspective of a patient or a clinician, the most attractive choice for a comparison group is one that uses what clinicians are currently using: the TAU (treatment-as-usual) control group. Here patients are recruited into the study and randomly assigned either to T, the new treatment under study, or to the treatment they would have received if they had not entered the RCT. The responses in both groups are monitored using the same protocol, with evaluators blinded to group membership. The research question is whether it can be shown, beyond reasonable doubt, that T produces better results than what community clinicians generally achieve.

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