Serotonin | Norepinephrine | Dopamine
The action of any SSRI extends beyond the inhibition of 5-HT
reuptake. At least 14 different 5-HT receptor subtypes reside at
pre- and postsynaptic locations (Fuller 1996). Serotonin1A (5-HT1A)
binding sites include both somatodendritic and presynaptic autoreceptors
(which inhibit 5-HT firing) and postsynaptic receptors. The latter are
predominantly hippocampal, and their sensitivity is increased after
chronic antidepressant exposure (Aghajanian et al. 1988; Elena Castro et al. 2003).