Sections
Trazodone and Nefazodone: Introduction | Trazodone | Nefazodone | Conclusion | References
Excerpt
Trazodone was among the earliest "second
generation" antidepressants to become available for clinical
use in the United States in the early 1980s. Its side-effect profile
and potential toxicity were considerably different from and, in many
instances preferable to, those of the original antidepressants (i.e.,
the monoamine oxidase inhibitors [MAOIs] and tricyclic
antidepressants [TCAs]). Several years later,
its pharmacological "cousin," nefazodone, joined
the growing armamentarium of effective antidepressant medications.