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Trazodone's sedative properties and association with orthostatic hypotension eventually inspired an effort to discover a modified molecule, utilizing receptor-binding techniques, which would possess a more desirable pharmacological profile. This led to the development of nefazodone (Taylor et al. 1986), which became available for clinical use in the United States in 1994. Nefazodone can be considered a member of the trazodone family because they share a common active metabolite.

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FIGURE 19–2. Chemical structure of nefazodone.

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