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FIGURE 22–2. Rate differences for remission and 95% confidence intervals for venlafaxine versus selective serotonin reuptake inhibitors (SSRIs).

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FIGURE 22–2. Rate differences for remission and 95% confidence intervals for venlafaxine versus selective serotonin reuptake inhibitors (SSRIs).Remission is defined as a 17-item Hamilton Rating Scale for Depression (Ham-D-17) score of 7 or less for 33 of the 34 studies. One study (4229; Allard et al. 2004) did not use the Ham-D, and remission was defined as a Montgomery-Åsberg Depression Rating Scale score of 10 or less. Remission rate differences for the individual studies ranged from –7% to 31%; differences numerically favored venlafaxine in 28 studies (although only 5 reached statistical significance), with 6 studies numerically favoring the SSRIs.Source. Reprinted from Nemeroff CB, Entsuah R, Benattia I, et al.: "Comprehensive Analysis of Remission (COMPARE) With Venlafaxine Versus SSRIs." Biological Psychiatry 63:424–434, 2008. Copyright 2008, Elsevier. Used with permission.

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