0
0

Sections

Excerpt

To date, 12 placebo-controlled studies have evaluated the antidepressant efficacy of duloxetine at dosages of 40–120 mg/day. Many of these had an active drug comparator group. Efficacy was measured by remission, the optimal outcome measure, or by response. Remission can be operationally defined as a score of less than or equal to 7 on the 17-item Hamilton Rating Scale for Depression (Ham-D) or a score of less than or equal to 10 on the Montgomery-Åsberg Depression Rating Scale (MADRS). Response is often defined as a 50% reduction in the MADRS or Ham-D score from baseline to endpoint. These studies and non-placebo-controlled duloxetine trials are summarized in Tables 23–2 and 23–3.

Your session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

Table Reference Number
TABLE 23–2. Duloxetine versus placebo and/or active SSRI or SNRI comparator in acute studies (12 weeks) of depression
Table Reference Number
TABLE 23–3. Duloxetine versus placebo and/or active SSRI comparator in continuation studies (>12 weeks) of depression
Table Reference Number
TABLE 23–4. Milnacipran versus placebo and/or active SSRI comparator in acute studies (12 weeks) of depression

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Related Content
Articles
Books
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 3.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 11.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 26.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 23.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 24.  >
Psychiatric News
Read more at Psychiatric News >>
PubMed Articles
 
  • Print
  • PDF
  • E-mail
  • Chapter Alerts
  • Get Citation