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FIGURE 26–3. Results from an open-label proof-of-concept study suggest the potential usefulness of a CRH1 receptor antagonist in severely depressed patients.

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FIGURE 26–3. Results from an open-label proof-of-concept study suggest the potential usefulness of a CRH1 receptor antagonist in severely depressed patients.Two patient samples (n = 10 each) with severe major depression were treated with R 121919, a selective high-affinity CRH1 receptor antagonist. Two different dosage escalation panels with weekly increases from 5–20 mg to 40 mg (black lines) and from 40–60 mg to 80 mg (green lines) were administered, resulting in significantly decreased severity scores on both depression (Hamilton Rating Scale for Depression [Ham-D]) and anxiety (Hamilton Anxiety Scale [Ham-A]) scales. Note that after cessation of active treatment, clinical worsening of depressive and anxiety symptoms was observed. CRH = corticotropin-releasing hormone 1 receptor.Source. Adapted from Zobel et al. 2000.

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