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FIGURE 33–6. Time course of weight change over 58 weeks after switching to ziprasidone.Previous treatments were conventional antipsychotics (line with circles; n = 71), risperidone (line with squares; n = 43), or olanzapine (line with triangles; n = 71). Individual observed cases within each treatment group are also shown (circle = conventional agent: baseline weight, 198 lb [90 kg]; square = risperidone: baseline weight, 194.9 lb [88.6 kg]; triangle = olanzapine: baseline weight, 210.3 lb [95.6 kg]).LS = least-squares analysis; MMRM = mixed-model repeated measures analysis; OC = observed case analysis.*P <0.01 versus baseline (MMRM and OC).Source. Adapted from Weiden PJ, Newcomer JW, Loebel AD, et al.: "Long-Term Changes in Weight and Plasma Lipids During Maintenance Treatment With Ziprasidone." Neuropsychopharmacology 33:985–994, 2008 (Figure 1, p. 988).

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