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Benztropine was synthesized by uniting the tropine portion of atropine with the benzhydryl portion of diphenhydramine hydrochloride. Benztropine was found to be effective in the treatment of 302 patients with Parkinson's disease (Doshay 1956). The best results in the control of rigidity, contracture, and tremor were obtained at doses of 1–4 mg qd for older patients and 2–8 mg qd for younger ones. Doses of 15–30 mg qd caused excessive flaccidity in some patients, who became unable to lift their arms or raise their heads off the bed. Subsequently, benztropine was found to be effective for the treatment of NIP (Karn and Kasper 1959).

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