History and Discovery | Structure–Activity Relations | Pharmacological Profile | Pharmacokinetics and Disposition | Mechanism of Action | Indications and Efficacy | Side Effects and Toxicology | Drug–Drug Interactions
Antihistaminic agents have been used for the treatment of Parkinson's
disease. Diphenhydramine, one of the first antihistamines developed
and used clinically (Bovet 1950), has been the primary
antihistamine studied in the treatment of EPS. Although some antihistamines
may be effective, other antihistamines have not been systematically
studied for the treatment of EPS.