History and Discovery | Structure–Activity Relations | Pharmacological Profile | Pharmacokinetics and Disposition | Mechanism of Action | Indications and Efficacy | Side Effects and Toxicology | Drug–Drug Interactions
Propranolol was reported to be effective for the treatment of
restless legs syndrome (Ekbom's syndrome; Ekbom 1965),
which resembles the physical movements of akathisia (Strang 1967). Later it was reported to be effective in the treatment
of neuroleptic-induced akathisia (Kulik and Wilbur 1983; Lipinski et al. 1983). Subsequently, other -blockers
have also been investigated for the treatment of akathisia.