History and Discovery | Mechanism of Action | Indications and Efficacy
Diazepam was initially shown to be effective in the treatment
of restless legs syndrome (Ekbom's syndrome), which resembles
the physical movements of akathisia (Ekbom 1965). Subsequently,
diazepam, lorazepam, and clonazepam were reported to be beneficial
for neuroleptic-induced akathisia (Adler et al. 1985; Donlon 1973; Kutcher et al. 1987). Clonazepam has also
been reported to be beneficial for drug-induced dystonia (O'Flanagan 1975) and TD (Thaker et al. 1987).