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Diazepam was initially shown to be effective in the treatment of restless legs syndrome (Ekbom's syndrome), which resembles the physical movements of akathisia (Ekbom 1965). Subsequently, diazepam, lorazepam, and clonazepam were reported to be beneficial for neuroleptic-induced akathisia (Adler et al. 1985; Donlon 1973; Kutcher et al. 1987). Clonazepam has also been reported to be beneficial for drug-induced dystonia (O'Flanagan 1975) and TD (Thaker et al. 1987).

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