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Gabapentin currently is FDA approved as an adjunctive treatment for partial seizures with and without secondary generalization in adults with epilepsy ("Neurontin" 2006). This indication was based on controlled evaluations of gabapentin at daily doses of 600–1,800 mg. Additional research has reported efficacy and tolerability for gabapentin monotherapy at daily dosages up to 4,800 mg in patients with refractory epilepsy (Beydoun et al. 1998). There is no established therapeutic plasma level for seizure control. Gabapentin has a highly desirable side-effect profile. Only mild side effects (sedation, dizziness, and ataxia) have been commonly reported.

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