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Several placebo-controlled studies have evaluated pregabalin in the treatment of patients with refractory partial epilepsy (Elger et al. 2005; Hamandi and Sander 2006). Response rates for pregabalin dosed at 600 mg/day were similar to those reported in other trials of antiepileptic drugs in refractory epilepsy. The study by Elger et al. (2005) showed that pregabalin administered in either fixed or flexible doses was highly effective and generally well tolerated as add-on therapy for partial seizures with or without secondary generalization.

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