0
0

Sections

Excerpt

Before 1900, a few agents, such as bromide, chloral hydrate, paraldehyde, urethane, and sulfonal, were used as sedatives and hypnotics. Barbital, one of the derivatives of barbituric acid, was introduced in 1903 and soon became extremely popular in clinical medicine because of its sleep-inducing and anxiolytic effects (Maynert 1965). In 1912, phenobarbital was introduced. In addition to its use as a sedative-hypnotic, phenobarbital has become one of the most important pharmacological treatments for epilepsy. Since then, more than 2,500 barbiturate analogs have been synthesized, about 50 of which have been made commercially available and only 20 of which remain on the market.

Your session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

FIGURE 42–7. Structure–activity relations among barbiturates.

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Related Content
Articles
Books
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 1.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 6.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 7.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 8.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 12.  >
Psychiatric News
PubMed Articles
Anxiolytic property of Lactuca sativa, effect on anxiety behaviour induced by novel food and height. Asian Pac J Trop Med 2013;6(7):532-6.doi:10.1016/S1995-7645(13)60091-7.
 
  • Print
  • PDF
  • E-mail
  • Chapter Alerts
  • Get Citation