Structure–Activity Relations | Pharmacokinetics and Disposition | Mechanism of Action | Side Effects and Toxicology | Drug–Drug Interactions
Although methylphenidate has two chiral centers, only one
contributes to its clinical effect. The d-
and l-threo enantiomers are in a
racemic mixture, although a single-isomer form of methylphenidate,
is currently being marketed under the brand name Focalin. There
are some differences in the pharmacological parameters of the two
isomers, as described in the following subsection.