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FIGURE 48–1. Pathological hallmarks of Alzheimer's disease.

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FIGURE 48–1. Pathological hallmarks of Alzheimer's disease.(A) Low-magnification view of cerebral cortex showing multiple A-immunopositive plaques. (B) Higher magnification of a Bielschowsky silver stain showing argyrophilic amyloid plaques (arrow) and neurofibrillary tangles (arrowhead) in cerebral cortex. (C) High-magnification view of a single neuritic plaque. The central core of the plaque contains amyloid peptides that are surrounded by a clear halo and then swollen silver-positive dystrophic neurites. (D) High-magnification view of a neurofibrillary tangle.

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