Acute Treatment | Continuation Treatment | Maintenance Treatment
The goal of acute treatment of an individual with major depressive
disorder is to identify a medication or psychotherapy that is effective
and treat the individual vigorously enough to help him or her achieve
remission. Recently, most of our understanding of acute treatment
has been derived from Phase II and Phase III industry-sponsored
studies of antidepressants. Many of these short-term studies were
designed to differentiate an investigational compound from placebo.
The goal of these trials was not to achieve disease remission but
rather to demonstrate that the investigational compound was more
efficacious than a placebo compound.