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Risperidone is the atypical antipsychotic most studied for the treatment of Tourette's syndrome and tic disorders. Risperidone was compared with pimozide in a 12-week double-blind, placebo-controlled multicenter study of 50 patients (ages 10–65 years) with Tourette's syndrome. Patients treated with both risperidone (mean daily dose = 3.8 mg) and pimozide (mean daily dose = 2.9 mg) showed significant improvement on the Tourette's Syndrome Severity Scale (TSSS; Shapiro et al. 1988). Fourteen of 26 patients (54%) treated with risperidone and 9 of 24 patients (38%) treated with pimozide had very mild or no symptoms on the TSSS at endpoint. Fewer patients treated with risperidone than with pimozide reported extrapyramidal side effects. Side effects common to both treatment groups were depression, fatigue, and somnolence (Bruggeman et al. 2001).

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